The Effect of Coffee Arabica Gayo Leaf Extract (Coffea arabica L.) on Increased PI3K Serum Levels in Type 2 Diabetic Rat
نویسندگان
چکیده
BACKGROUND: Coffee arabica gayo leaf extract (Coffea L.) contains polyphenols (chlorogenic acid), flavonoids, saponins, tannins, and steroids which improved PI3K serum levels in rats type 2 diabetic rat. AIM: The purpose of the study was to determine effect Arabica Gayo Leaf Extract (C. on increased type-2 rat (Rattus norvegicus). METHODS: Thirty-five male Wistar with induced a combination feeding high-fat diet for 5 weeks intraperitoneal injection low dose streptozotocin (30 mg/kg). were randomly divided into seven groups consist group without diabetic, 250 mg/kg/day Extract, intervention, metformin, doses 150, 200, mg/kg/day. administered orally 30 days. Subsequently, measure by Sandwich Elisa. RESULTS: There significantly higher treatment than control (p = 0.037) after giving 200 CONCLUSION: These data suggest that can improve model diabetic.
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ژورنال
عنوان ژورنال: Open Access Macedonian Journal of Medical Sciences
سال: 2021
ISSN: ['1857-9655']
DOI: https://doi.org/10.3889/oamjms.2021.6344